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The diagnostic sensitivities and specificities of each assay were determined using 39 S. Most of what is known about the genetic basis of kidney cancer has been learned from study of the inherited forms of kidney cancer: von Hippel Lindau VHL genehereditary papillary renal carcinoma c-Met geneBirt Hogg Dubé BHD geneand hereditary leiomyomatosis renal cell cancer fumarate hydratase gene. We confirmed HES1, NOTCH1 and NRARP as Notch target genes, but other reported Notch targets, including the genes for Deltex1, pre-T-cell receptor alpha and E2A, were not found to be differentially expressed.

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